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目的:调查2000~2004年福州市戊型肝炎流行情况。方法:检测健康人群及慢性肝炎、肝硬化患者血清中抗HEV抗体E2-IgG,并用HEV单克隆抗体(8C11和8H3)阻断实验确证阳性血清,回顾性统计急性散发性肝炎中,甲型肝炎及戊型肝炎的分布情况。结果:急性散发性肝炎中,甲型肝炎的发病率平稳降低,而戊型肝炎的发病率逐年升高。163例健康体检人群中,E2-IgG的总阳性率为41.1%,感染率与年龄显著相关;随着年龄的递增每年感染率平均增加0.8%。成年男性与女性的平均感染率无统计学意义(P>0.05)。慢性肝炎和肝硬化患者中,E2-IgG的阳性率分别为37.4%和53.1%;男性与女性的总感染率无统计学意义(P>0.05)。阻断实验的结果确证,E2-IgG阳性的血清均为抗HEV抗体阳性。结论:HEV的感染率与年龄密切相关,且随年龄的增长而增长。福州市急性散发性肝炎病例中,戊型肝炎的感染率和发病率逐年升高,为急性肝炎的最主要病因。该市已成为戊型肝炎的高流行区,应当引起有关部门的重视。
Objective: To investigate the prevalence of hepatitis E in Fuzhou from 2000 to 2004. Methods: Serum anti-HEV antibody E2-IgG was detected in healthy people and in patients with chronic hepatitis and cirrhosis, and positive serums were blocked by HEV monoclonal antibody (8C11 and 8H3). Retrospective statistics of hepatitis A And hepatitis E distribution. Results: In acute sporadic hepatitis, the incidence of hepatitis A decreased steadily while the incidence of hepatitis E increased year by year. The total positive rate of E2-IgG in 163 healthy people was 41.1%. The infection rate was significantly related to age. The average annual infection rate increased by 0.8% with increasing age. The average infection rate of adult males and females was not statistically significant (P> 0.05). The positive rates of E2-IgG in patients with chronic hepatitis and cirrhosis were 37.4% and 53.1% respectively. There was no significant difference between male and female (P> 0.05). The result of the blocking experiment confirmed that E2-IgG positive sera were all positive for anti-HEV antibodies. Conclusion: The infection rate of HEV is closely related to age and increases with age. Among the cases of acute sporadic hepatitis in Fuzhou, the infection rate and incidence of hepatitis E are increasing year by year, which is the most important cause of acute hepatitis. The city has become a high endemic area of hepatitis E, which should arouse the attention of relevant departments.