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目的:探究多发性骨髓瘤(MM)患者荧光原位杂交(FISH)结果与临床特征之间的关系。方法:回顾性统计57例初诊MM患者的临床特征及FISH检测的遗传学异常(其中17例患者经CD138磁珠分选),分析其间的关系。结果:D13S319缺失和RB1缺失均与更高水平的乳酸脱氢酶(LDH)(P=0.024;P=0.018)及骨髓瘤细胞比例相关(P=0.027;P=0.013)。1q21扩增与更高水平的LDH量相关(P=0.030),与轻链型骨髓瘤发生相关(P=0.023)。IgH重排与患者发生肾功能损伤相关(P=0.009)。D13S319缺失、1q21扩增、RB1缺失及Ig H重排之间均两两相关(P<0.01)。结论 :FISH检测的MM患者遗传学异常与多种临床预后指标相关,对于更完善地评估患者的病情及预后有较大作用。
Objective: To investigate the relationship between the results of FISH and clinical features in patients with multiple myeloma (MM). Methods: The clinical characteristics of 57 newly diagnosed MM patients and the genetic abnormalities detected by FISH were retrospectively analyzed (17 of them were sorted by CD138 magnetic beads), and the relationship between them was analyzed. RESULTS: Both D13S319 deletion and RB1 deletion were associated with higher levels of lactate dehydrogenase (LDH) (P = 0.024; P = 0.018) and myeloma cells (P = 0.027; P = 0.013). The 1q21 amplification was associated with a higher level of LDH (P = 0.030), which was associated with the occurrence of mild myeloma (P = 0.023). IgH rearrangement was associated with impaired renal function (P = 0.009). D13S319 deletion, 1q21 amplification, deletion of RB1, and Ig H rearrangement were all correlated (P <0.01). CONCLUSIONS: Genetic abnormalities in MM patients detected by FISH correlate with a variety of clinical prognostic indicators, which may be useful in better assessing the patient’s condition and prognosis.