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目的 :观察妊高征患者血浆一氧化氮 (NO)和内皮素 (ET)含量的变化并探讨其在妊高征发病中的意义。方法 :应用镉柱比色法和放射免疫法分别对 43例妊高征患者 (妊高征组 )、36例正常妊娠妇女 (对照组 )和 19例正常非孕妇 (正常组 )血浆中NO代谢产物亚硝酸盐 /硝酸盐 (NO-2 /NO-3 )及ET - 1含量进行了检测。结果 :正常妊娠妇女血浆中NO-2 /NO-3 含量 (34.2 9± 10 .15 ) μmol/L明显高于非孕正常组妇女 (11.98± 3 .99)μmol/L ,并随孕周的增加而增加 ,孕中期达高峰 (39.45± 9.16 ) μmol/L ,到孕晚期有所下降 (31.42± 7.86 5 )μmol/L。血浆中ET的含量有所上升 ,但与非孕正常组妇女相比则没有显著差异 (P >0 .0 5 ) ;与正常晚期妊娠对照组相比 ,轻、中度妊高征妇女血浆中NO-2 /NO-3 含量虽有所上升 ,但没有明显差异 (P >0 .0 5 ) ,而重度妊高征妇女则有明显上升 (P <0 .0 5 )。妊高征妇女血浆ET含量 (96 .0 5± 13 .5 7)ng/L与正常晚期妊娠妇女(36 .48± 6 .17ng/L)相比有极显著的上升 (P <0 .0 1) ,并且与妊高征的严重程度成正比 (r =0 .5 2 ,P <0 .0 1) ,ET/NO比值 (2 .47)明显大于正常晚期妊娠对照组妇女 (1.13,P <0 .0 5 )。结论 :妊高征患者内皮细胞损伤导致ET/NO系统平衡失调可能在妊高征的发病机
Objective: To observe the changes of plasma nitric oxide (NO) and endothelin (ET) levels in patients with pregnancy induced hypertension and to explore its significance in the pathogenesis of pregnancy induced hypertension. Methods: Plasma concentrations of NO in 43 PIH patients, 36 normal pregnant women (control group) and 19 normal non-pregnant women (normal group) were determined by the method of cadmium column chromatography and radioimmunoassay. The contents of nitrite / nitrate (NO-2 / NO-3) and ET-1 were detected. Results: The plasma level of NO-2 / NO-3 in normal pregnant women (34.2 9 ± 10.15 μmol / L) was significantly higher than that in non-pregnant women (11.98 ± 3.99) μmol / L, (39.45 ± 9.16) μmol / L in the second trimester, and decreased to 31.42 ± 7.86 5 μmol / L in the third trimester of pregnancy. The content of ET in plasma increased, but there was no significant difference compared with non-pregnant normal women (P> 0.05). Compared with the control group of normal late pregnant women, the plasma levels of ET Although the content of NO-2 / NO-3 increased, there was no significant difference (P> 0.05), while the incidence of severe PIH increased significantly (P <0.05). The plasma ET level in PIH patients (96.5 ± 13.57ng / L) was significantly higher than that in normal late pregnant women (36.48 ± 6.17ng / L) (P <0. 0 1), and was proportional to the severity of PIH (r = 0.52, P <0.01). The ET / NO ratio (2.47) was significantly higher than that of women with normal late pregnancy (1.13, P <0 .0 5). Conclusion: The imbalance of ET / NO system caused by endothelial cell injury in patients with PIH may be the pathogenesis of PIH