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肥胖病是心脏病的危险因素,传统观点认为,在肥胖患者中,由于血流动力学异常和脂代谢异常导致的心脏重构是患者易发展为冠状动脉性疾病和心力衰竭的原因。但最近研究发现,脂肪在心脏沉积可以直接损伤心脏,影响左室重建,导致扩张型心肌病。对肥胖动物模型的研究发现,心肌中脂质过度沉积可导致左室肥厚和缺血性、扩张型心肌病。通过基因治疗或药物干预降低心脏的脂质沉积,可以预防肥胖相关性心脏病的发生。临床研究也提示,心肌的脂质含量可以作为肥胖患者心脏病的生物指标,并且可以成为治疗的靶点。但这方面的研究才刚刚开始,有待进一步的研究。
Obesity is a risk factor for heart disease. Traditionally, cardiac remodeling due to abnormal hemodynamics and lipid metabolism in obese patients is thought to be responsible for the development of coronary artery disease and heart failure in obese patients. However, recent studies have found that fat deposition in the heart can directly damage the heart, affecting left ventricular remodeling, leading to dilated cardiomyopathy. Studies of obese animal models found that excessive lipid deposition in the myocardium can lead to left ventricular hypertrophy and ischemic, dilated cardiomyopathy. By gene therapy or drug intervention to reduce heart lipid deposition, can prevent the occurrence of obesity-related heart disease. Clinical studies also suggest that the lipid content of myocardium may serve as a biological indicator of heart disease in obese patients and may be a therapeutic target. However, research in this area has just begun, pending further study.