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作者等多年来从事于筛选韩国产药用植物中的血小板活化因子(PAF)抑制剂。曾从柏科植物侧柏Biotaorientalis(L.)Endl.中分得pinusolide和雪松醇(cedrol)2个化合物。其抑制PAF和免血小板受体结合的IC50分别为2.5×10-7mol/L[(0.87±0.009)μg/mL]和1.3×10-5mo
The authors have been engaged in the screening of platelet activating factor (PAF) inhibitors in Korean medicinal plants for many years. Biota Orientalis (L.) Endl. Two compounds were isolated: pinusolide and cedrol. Its IC50 for inhibiting the binding of PAF and platelet-free receptor is 2.5×10-7mol/L [(0.87±0.009)μg/mL] and 1.3×10-5mo, respectively.