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许多化疗药物对头颈部鳞癌是有效的。最有效的药物为顺铂、氨甲喋呤及博莱霉素,曾报导晚期复发性肿瘤的有效率大约是30%。以顺铂为基础的联合方案对以往未治疗的病人一般都有较高的疗效,而对曾手术或放疗过的病人则疗效较差。作者曾报导单用5-Fu 治疗曾治疗过的头颈部鳞癌病人有效率为31%。由于5-Fu 大剂量推注可增加骨髓抑制,故采用了5-Fu 连续滴注的给药方法。本组共35例Ⅱ一Ⅳ期的头颈部鳞癌病人,均有局部可测量病灶但无远处转移。男性27例,女性8例。除1例外均为Ⅳ期。分化良好的鳞癌1例,中等分化
Many chemotherapy drugs are effective for head and neck squamous cell carcinoma. The most effective drugs are cisplatin, methotrexate, and bleomycin, and it has been reported that the effective rate of late recurrent tumors is about 30%. The cisplatin-based combination regimen generally has a higher therapeutic effect on previously untreated patients and is less effective on patients who have undergone surgery or radiation therapy. The authors reported that the effective rate of patients with head and neck squamous cell carcinoma treated with 5-Fu alone was 31%. Because 5-Fu high-dose bolus injection can increase bone marrow suppression, 5-Fu continuous instillation was used. A total of 35 patients with stage II-IV head and neck squamous cell carcinoma in this group had locally measurable lesions but no distant metastases. There were 27 males and 8 females. All except one exception are Phase IV. One well-differentiated squamous cell carcinoma, moderately differentiated