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解决冠心病的问题是预防。但尽管对此给予大力的研究,至今尚无确立有效的预防措施。这一领域的研究主要是关于脂质和脂蛋白,然而,其与冠心病发生的关系仍然迷惑不解。过去10年,发现在冠心病患者,葡萄糖耐量异常和摄入葡萄糖后胰岛素反应异常的发生率很高。大多数冠心病患者具有葡萄糖耐量异常、胰岛素反应异常、血清脂质异常或三者的某种联合。因此如能发现这些异常的机理,有可能解决冠心病的问题。最近,在年青男性心肌梗塞患者,意外地发现有些患者有女性化的征象,测定其血清性激素的浓度,发现雌二醇和雌酮的平均血清浓度增高,睾丸酮和去氢睾丸酮则与对照者无显著差异。进一步的资料分析显示,葡
The solution to coronary heart disease is prevention. However, no effective preventive measures have been established so far despite intensive research. The research in this area is mainly about lipids and lipoproteins, however, their relationship with coronary heart disease is still puzzled. Over the past 10 years, patients with coronary heart disease have been found to have a high incidence of abnormal insulin resistance due to impaired glucose tolerance and glucose intoxication. Most patients with coronary heart disease have impaired glucose tolerance, abnormal insulin response, abnormal serum lipid, or some combination of the three. Therefore, if these abnormal mechanisms can be found, it is possible to solve the problem of coronary heart disease. Recently, in young patients with acute myocardial infarction, it was unexpectedly found that some patients had signs of feminization. The serum concentrations of sex hormones were measured and the mean serum concentrations of estradiol and estrone were found to be elevated. Testosterone and dehydrotestosterone were not significantly different from those of controls difference. Further analysis of the data shows that Portugal