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目的:研究垂体后叶素联合催产素对腹腔镜下子宫肌瘤剔除术患者循环系统的影响及止血效果。方法:收集本院2011年10月至2013年10月进行腹腔镜下子宫肌瘤剔除术的75例子宫肌瘤患者,采用简单随机分组的方法将研究样本序贯分为A组(垂体后叶素组)、B组(催产素组)、C组(垂体后叶素联合催产素组)三组,各25例。比较各组循环系统和止血效果指标是否有变化及差异。结果:三组之间收缩压、舒张压、心率差异有统计学意义(P<0.05),不同时间的收缩压、舒张压、心率差异有统计学意义(P<0.05),收缩压、舒张压、心率分组与时间之间有交互作用(P<0.05)。A组较B组低血压、心动过速及出血量更少,B组较A组高血压、心动过缓更少,差异均有统计学意义(P<0.05);C组较A组高血压、心动过缓更少,差异有统计学意义(P<0.05);C组较B组低血压、心动过速及出血量更少,差异有统计学意义(P<0.05)。结论:腹腔镜下子宫肌瘤剔除术患者联合应用垂体后叶素与催产素后循环波动小,止血效果好,值得在临床上推广应用。
Objective: To study the effect of pituitrin combined with oxytocin on circulatory system in patients undergoing laparoscopic myomectomy and the effect of hemostasis. Methods: A total of 75 patients with uterine leiomyoma who underwent laparoscopic myomectomy from October 2011 to October 2013 were enrolled in this study. Patients were randomly divided into group A (posterior pituitary) Group), group B (oxytocin group), group C (group of pituitrin combined with oxytocin) and group of 25 patients. Compare each group of circulatory system and hemostatic effect indicators have changes and differences. Results: The systolic blood pressure, diastolic blood pressure and heart rate were significantly different among the three groups (P <0.05). The systolic blood pressure, diastolic blood pressure and heart rate had statistical significance at different time points (P <0.05) , There was interaction between heart rate group and time (P <0.05). A group than in group B hypotension, tachycardia and bleeding less, B group than in group A hypertension, bradycardia less, the difference was statistically significant (P <0.05); C group than in group A hypertension , Bradycardia less, the difference was statistically significant (P <0.05); C group than in group B hypotension, tachycardia and bleeding less, the difference was statistically significant (P <0.05). Conclusion: Laparoscopic myomectomy in patients with combined application of pituitrin and oxytocin circulation after the small fluctuations, hemostatic effect, it is worth popularizing the clinical application.