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目的 探讨胃癌C -erbB -2、PCNA表达及其与病理分化程度、浸润、转移的生物学行为间的关系。 方法 采用S -P法 ,对胃癌组织切片中C -erbB -2和PCNA进行免疫组化标记及原位观察 ,统计其与胃癌临床病理生物学行为间的相关性。结果 48例中C -erbB -2阳性表达65 % ,阳性程度与肿瘤组织的不同分化程度之间显著相关 ,PCNA阳性表达77 % ,阳性程度与淋巴结有否转移之间有显著相关。C -erbB -2与PCNA之间无密切关系。结论 C -erbB -2和PCNA检测可作为判断胃癌生物学行为和指导治疗的良好指标 ,但代表的临床意义不同。
Objective To investigate the relationship between the expression of C-erbB-2 and PCNA in gastric cancer and its biological behavior with the degree of differentiation, invasion and metastasis. Methods The expressions of C-erbB-2 and PCNA in gastric cancer tissue were immunohistochemically labeled and observed in situ using S-P method. The correlation between the expression of C-erbB-2 and PCNA in clinicopathological and biological behavior of gastric cancer was statistically analyzed. Results The positive expression of C-erbB-2 was significantly higher in 65 of 48 cases (P <0.05). The positive expression of C-erbB-2 was significantly associated with the differentiation of tumor. The positive expression of PCNA was 77%. There is no close relationship between C-erbB-2 and PCNA. Conclusion The detection of C-erbB-2 and PCNA can be used as a good indicator to judge the biological behavior and guidance of gastric cancer, but the clinical significance is different.