论文部分内容阅读
目的研究幽门螺杆菌 (HP)相关胃病的发病情况及与肠上皮化生和非典型增生的关系。方法 15 85例胃病患者在内窥镜检查时分别取胃窦部和胃体部粘膜组织作 Giemsa染色、快速尿素酶试验 (RUT)或1 4 C尿素呼气试验 (1 4 C-U BT) ,二项均为阳性则诊断为 HP感染。结果 15 85例中 HP阳性率 48.3% ,其中慢性萎缩性胃炎患者的感染率最高 (6 4.6 % ) ,胃癌患者次之 (6 2 .2 % )、十二指肠溃疡患者为 45 .3%、胃溃疡患者为 44.4%、慢性浅表性胃炎患者 40 .3%。 HP阳性的胃溃疡病、慢性萎缩性胃炎及慢性浅表性胃炎患者肠上皮化生和非典型增生的发生率明显高于 HP阴性患者 (P<0 .0 1～ 0 .0 5 )。结论 HP感染增加了胃癌的危险性
Objective To study the incidence of Helicobacter pylori (HP) related gastric diseases and its relationship with intestinal metaplasia and atypical hyperplasia. Methods Fifteen 85 cases of gastric diseases were examined by Giemsa staining, RUT or 14 C urea breath test (14 CU BT), mucosal tissues of gastric antrum and gastric body during endoscopy, Items were positive diagnosed with HP infection. Results The positive rate of HP in 15 85 cases was 48.3%, of which the highest infection rate was found in patients with chronic atrophic gastritis (6 4.6%), followed by gastric cancer (62.2%) and duodenal ulcer patients (45.3%), 44.4% of patients with gastric ulcer and 40.3% of patients with chronic superficial gastritis. The incidence of intestinal metaplasia and atypical hyperplasia in patients with HP-positive gastric ulcer, chronic atrophic gastritis and chronic superficial gastritis was significantly higher than that in HP-negative patients (P <0.01 ~ 0.05). Conclusion HP infection increases the risk of gastric cancer