哌二苯丁胺和苯乙哌啶治疗慢性腹泻

• 作 者: 容中生
• 出 处: 国外医学参考资料(内科学分册)
• 发表日期: 1977年03期
• 关键词: 苯乙哌啶 丁胺 阿托品 慢性腹泻 中枢神经系统 可待因 临床药理研究 肠道 全结肠切除 局限性肠炎

目前广泛使用苯乙哌啶(Diphenoxylate)和阿托品治疗腹泻,既可直接作用于肠道制止腹泻,又没有中枢神经系统的副作用。最近介绍苯乙哌啶的衍生物哌二苯丁胺(Loperamide)的作用更强、更特效、更长效。在健康试者的临床药理研究证明,哌二苯丁胺引起的便秘作用比苯乙哌啶强3倍、比可待因强50倍。

Diphenoxylate and atropine are widely used to treat diarrhea and can act directly on the intestine to stop diarrhea without the side effects of the central nervous system. Recently, the derivative of diphenoxylate (Loperamide) is more effective, more effective and more effective. Clinical pharmacology studies in healthy subjects have demonstrated that constipation caused by piperidine is 3 times more potent than phenylepidem and 50 times more potent than codeine.