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目的:观察中晚期食道癌影响引导适形调强放疗(IGRT)精确放疗同步化疗的疗效及不良反应。方法:2010年10月至2012年12月本院本科收治的中晚期食道癌患者56例,随机分为两组,治疗组28例,同步予以紫素(TXT)+顺铂(PPD)化疗,21 d为1周期,共2周期,1~3个月后,巩固化疗3~4周期;对照组28例,单纯IGRT精确放疗。结果:治疗组有效率85.7%,对照组有效率67.9%,主要不良反应为放射性食道炎、恶心、呕吐等消化道反应,骨髓抑制有统计学意义,治疗组完全脱发率100%。结论:中晚期食道癌IGRT精确放疗同步化疗安全有效,其不良反应患者可耐受。
OBJECTIVE: To observe the curative effect and adverse reactions of advanced esophageal cancer (ICG) -mediated esophageal stricture guided radiotherapy (IGRT) with radiotherapy. Methods: From October 2010 to December 2012, 56 patients with advanced esophageal cancer undergraduate admitted to our hospital were randomly divided into two groups. The treatment group was treated with TXT plus cisplatin (PPD) chemotherapy, 21 d for 1 cycle, a total of 2 cycles, 1 to 3 months after the consolidation of chemotherapy 3 to 4 cycles; control group of 28 patients, simple IGRT radiotherapy alone. Results: The effective rate was 85.7% in the treatment group and 67.9% in the control group. The main adverse reactions were gastrointestinal reactions such as radiation esophagitis, nausea and vomiting. The bone marrow suppression was statistically significant. The rate of complete alopecia in the treatment group was 100%. Conclusions: IGRT in advanced esophageal cancer is safe and effective with simultaneous radiotherapy and chemotherapy, and patients with adverse reactions can tolerate it.