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目的:探讨经皮冠脉介入术(PCI)后患者的纤维蛋白原和血小板高反应(HPPR)与支架内再狭窄(ISR)的相关性。方法:回顾性分析2011年9月至2012年8月收治的191例PCI术后患者的临床资料,其中150例无ISR(对照组)、41例ISR(试验组),对比两组患者年龄、性别、BMI、纤维蛋白原、血小板聚集功能以及植入支架数目等指标。结果:对照组和试验组患者的年龄、BMI、高脂血症、纤维蛋白原及HPPR比较,差异均有统计学意义(P<0.05)。纤维蛋白原水平和HPPR是ISR的独立危险因素(P<0.05)。结论:纤维蛋白原和HPPR可作为ISR的预测因素。
Objective: To investigate the correlation between fibrinogen and platelet hyperresponsiveness (HPPR) and in-stent restenosis (ISR) after percutaneous coronary intervention (PCI). Methods: The clinical data of 191 patients who underwent PCI between September 2011 and August 2012 were retrospectively analyzed. Among 150 patients without ISR (control group) and 41 with ISR (test group), the age, Gender, BMI, fibrinogen, platelet aggregation function and the number of implanted stents and other indicators. Results: The differences of age, BMI, hyperlipidemia, fibrinogen and HPPR between the control group and the test group were statistically significant (P <0.05). Fibrinogen levels and HPPR were independent risk factors for ISR (P <0.05). Conclusion: Fibrinogen and HPPR can be used as predictors of ISR.