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Objective To evaluate in vivo stability of ethylenedylbis cysteine diethylester (ECD) brain SPECT. Methods Each of 13 normal volunteers (31. 2 ± 11. 8 years) has 12 dynamic SPECK scans ac-quired in 60min 1h after an injection of 99mTc-ECD using a triple headed gamma camera equipped with ultra high resolution fan beam collimators. Average counts per pixel were measured from frontal, temporal, parie-tal, occipital regions, cerebellum, basal ganglia, thalamus and white matter. Regional ECD clearance rates, regional gray-to-white matter (G/W) ratios and the change of the G/W ratio were calculated. Results The average ECD clearance rate was 4. 2% /h, ranged from 3. 03% /h to 5. 41% /h corresponding to white matter and occipital. There was no significant difference between regional ECD clearance rates. Regional G 7W ratio was between 1.27 to 1.75. The G/W ratio of temporal lobe was lower than the occipital ( P <0.05). The change of regional G/W ratio with time is slow. Conclusion Regional ECD distribution is stable in normal brain. ECD clearance from brain is slow and no significant regional difference.
Objective To evaluate in vivo stability of ethylenedylbis cysteine diethylester (ECD) brain SPECT. Methods Each of 13 normal volunteers (31.2 ± 11. 8 years) has 12 dynamic SPECK scans ac-quired in 60 min 1 h after an injection of 99mTc-ECD using a triple headed gamma camera equipped with ultra high resolution fan beam collimators. Average counts per pixel were measured from frontal, temporal, parie-tal, occipital regions, cerebellum, basal ganglia, thalamus and white matter. Regional ECD clearance rates, regional gray Results Average ECD clearance rate was 4.2% / h, ranged from 3. 03% / h to 5. 41% Regional G 7W ratio was between 1.27 and 1.75. The G / W ratio of temporal lobe was lower than the occipital (P <0.05). There was no significant difference between regional ECD clearance rates. change of regional G / W ratio with time is slow. Conclusion Regional E CD distribution is stable in normal brain. ECD clearance from brain is slow and no significant regional difference.