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本文通过侧脑室注射神经生长因子（ＮＧＦ），研究其改善老年大鼠Ｍｏｒｒｉｓ水迷宫学习记忆损伤行为的作用。为分析信息获取能力，测量了５天训练的总潜伏期和训练末３天的后潜伏期。实验分为记忆损伤组、记忆非损伤组、ＮＧＦ组、人工脑脊液对照组，其后潜伏期分别为：４５．３ｓ，１０．２ｓ，２１．７ｓ和４８．７ｓ。ＮＧＦ组与其它三组比较有统计学差异（Ｐ＜０．０５）。从反映信息贮存能力的指标空间搜索实验来看，ＮＧＦ组比对照组表现出更好的定位性和趋向性，游泳轨迹以原平台象限占优势。平台象限的游泳距离百分比和跨平台次数百分比分别是对照组的２．１倍和２．４倍。然而各项指标均未达到记忆非损伤组的水平。表明ＮＧＦ能使记忆损伤组的信息获取和贮存能力部分恢复
In this study, we injected nerve growth factor (NGF) into the lateral ventricle to study its effect on learning and memory impairment of Morris water maze in aged rats. To analyze the information acquisition ability, the total latency of 5 days of training and the latency of 3 days of training were measured. The experiment was divided into memory injury group, non-memory injury group, NGF group and artificial cerebrospinal fluid control group. The latency period was 45.3s, 10.2s, 21.7s and 48.7s respectively. NGF group compared with the other three groups were statistically significant (P <0.05). From the index space search experiment that reflects the information storage capacity, NGF group showed better localization and tropism than the control group, and the swimming trajectory dominated the original platform quadrant. The percentage of swimming distance and cross-platform percentage of the platform quadrant were 2.1 and 2.4 times that of the control group, respectively. However, all the indexes did not reach the level of memory non-injury group. It shows that NGF can partly restore the information acquisition and storage ability of memory impairment group