论文部分内容阅读
患者,男,41岁。主因进行性上腹部疼痛,伴食欲下降,于1995年10月来院就诊。查体:一般情况好,表浅淋巴结不大。上腹部压痛明显.未扪及明显包块,肝脾不大。胃镜检查诊为胃管状腺癌。于1995午11月5日入院行胃癌根治术。术后病理诊断同胃镜诊断。术后1个月进行化疗。拟给予康莱特注射液100ml,静脉滴注.每日1次,20天为一疗程。第1天注射康莱特15分钟后病人出现头晕.周身不适.无恶心呕吐.立即停止输液,头晕症状逐渐消失。第2天继用此药.上述症状又复发,停止应用康莱特后消失。改用阿霉素、丝裂霉素,5氟脲嘧啶化疗后头晕症状未再出现。 讨论:患者在未用康莱特治疗前无头晕病史,在静滴康莱特注射液2次治疗中均出现头晕及周身不适.停用此药后症状逐渐消失,改用其它化疗方案后头晕未再出现,故头晕是由康莱特注射液所致。其机理尚不明确,有待于进一步探讨。
Patient, male, 41 years old. Mainly due to progressive upper abdominal pain, with loss of appetite, came to hospital in October 1995. Physical examination: the general situation is good, superficial lymph nodes are not. Upper abdominal tenderness obviously not palpable mass, small spleen and liver. Gastroscopy diagnosis of gastric tubular adenocarcinoma. On November 5, 1995 admission to gastric cancer radical mastectomy. Postoperative pathological diagnosis with endoscopy diagnosis. One month after chemotherapy. To be given Kanglaite injection 100ml, intravenous infusion. Daily 1, 20 days for a course of treatment. The patient became dizzy after 15 minutes of injection of Kanglaite on day 1. The whole body was not discomfort, no nausea and vomiting, the infusion was stopped immediately, and the symptom of dizziness gradually disappeared. Continue to use this medicine on the second day. The above symptoms recurrence, disappeared after stopping the application of KLT. Switch to doxorubicin, mitomycin, 5-fluorouracil dizziness after chemotherapy symptoms no longer appear. DISCUSSION: The patient had no history of dizziness before treatment with KLT, and dizziness and discomfort occurred in both treatments of intravenous Kanglaite injection. After the drug was stopped, the symptoms gradually disappeared and dizziness was not observed after switching to other chemotherapy regimens Appear, so dizzy is caused by Kanglaite injection. The mechanism is not yet clear and needs to be further explored.