论文部分内容阅读
以京尼平为交联剂,制备了壳聚糖(C)改性明胶(G)p H敏感型复合物(在本文中以Poly G-C表示);并采用微乳液法制备了Poly G-C纳米微球,用傅里叶红外光谱(FT-IR)、差热分析(DTA)、热重分析(TG)、扫描电子显微镜(SEM)对产物的结构及形貌进行了表征;考察了影响制备Poly G-C微球粒径的主要因素,测量了微球在p H=6.4及p H=7.4缓冲溶液中的吸水率。结果表明,通过京尼平交联的Poly G-C能形成分散性好、粒径分布在150~200nm的微球;乳化剂浓度、水油比、剪切速率、交联时间等均会影响粒径大小;Poly G-C微球在p H=6.4和p H=7.4的介质中,24h吸水率分别为4.2%和2.9%,且在p H=6.4的介质中,24h以后出现溶蚀现象,说明其具有p H敏感性。
Polygamid (C) modified gelatin (G) p H-sensitive complex (denoted by Poly GC) was prepared with genipin as crosslinking agent. Poly GC nanocrystals The structure and morphology of the product were characterized by Fourier transform infrared spectroscopy (FTIR), differential thermal analysis (DTA), thermogravimetric analysis (TG) and scanning electron microscopy (SEM) The main factor of the particle size of GC microspheres was measured the water absorption of the microspheres in p H = 6.4 and p H = 7.4 buffer solution. The results show that poly GC with cross-linking of genipin can form microspheres with good dispersibility and particle size distribution in the range of 150-200nm. The concentration of emulsifier, water-oil ratio, shear rate and crosslinking time all affect the particle size Polyglucose microspheres had a water uptake of 4.2% and 2.9% at pH 7.4 and p H = 7.4, respectively, and showed dissolution after 24h at pH 6.4, indicating that they had p H sensitivity.