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胃与十二指肠溃疡常常影响同一家族中一个以上的成员。这可能是由于偶合,即对同样的环境有相似的反应,也可能是由于有一个共同的遗传因素。对家族的研究表明,如一个家族中有若干成员都患有溃疡病,则其溃疡均趋向于同一类型,且各代成员中发生溃疡病的倾向也大致相等。这是存在遗传因素的证据。 Ian Aird等发现消化性溃疡在O型的人中特别多见。这个发现已多次被证实,并由于下述发现而得到发展,即那些不能在他们的分泌物中产生水溶性ABO(H)血型物质的人,也特别易发生溃疡(这个特性是遗传的,与ABO血型无关)。另外还发现溃疡的并发症尤其是出血,特别易出现于O型的人。 Lam等最近提出,在十二指肠溃疡患者中,ABO
Stomach and duodenal ulcers often affect more than one member of the same family. This may be due to coupling, ie a similar response to the same environment, or to a common genetic element. Research on families shows that if several members of a family have ulcer disease, their ulcers tend to be of the same type, and the incidence of ulcer disease among generations is approximately the same. This is evidence of genetic factors. Ian Aird and others found that peptic ulcers are particularly prevalent in O-type people. This finding has been repeatedly demonstrated and developed as a result of the finding that those who can not produce water-soluble ABO (H) blood group substances in their secretions are also particularly prone to ulcers (this property is hereditary, Has nothing to do with the ABO blood group). In addition, it was found that complications of ulcers, especially bleeding, are particularly prevalent in O-type people. Lam et al. Recently proposed that in patients with duodenal ulcers, ABO