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作者以健康志愿者为对照,前瞻性研究肝肾功能不全病人静脉注射洋地黄毒甙后的药物动力学参数,以了解有否蓄积现象。方法:受试者为健康成人8(男5,女2)例和肝肾功能不全病人8(男4,女4)例。后者均为酒精性或肝炎后性肝硬化,经活检证实。试验前一天测得病人组的肌酐清除率较健康组为低(19.6±2.9对(131.8±6.2ml/min,均值±标准误,下同),作为肝功能指标的安替比林清除率也较低(25.6±3.2对48.3±5.2ml/min)而半衰期较长(21.3±2.0对12.5±1.1hr)。
The author of healthy volunteers as a control, prospective study of patients with liver and kidney dysfunction after intravenous injection of digoxigenin pharmacokinetic parameters to understand whether the phenomenon of accumulation. Methods: The subjects were 8 healthy adults (5 males and 2 females) and 8 patients (4 males and 4 females) with liver and kidney insufficiency. The latter are alcoholic or posthepatitic cirrhosis confirmed by biopsy. Creatinine clearance was lower in the patient group than in the healthy group on the day before the test (19.6 ± 2.9 vs. 131.8 ± 6.2 mL / min, mean ± standard error, the same applies below), and also as an indication of liver function Lower (25.6 ± 3.2 vs. 48.3 ± 5.2 ml / min) and longer half-lives (21.3 ± 2.0 vs. 12.5 ± 1.1 hr).