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目的研究p28GANK在乙肝相关性肝癌组织中表达的临床意义。方法收集乙肝相关的肝癌及对应癌旁组织,采用免疫组织化学检测p28GANK肝癌及其对应癌旁组织中表达差异;分析其在肝癌组织中表达水平与患者临床参数的相关性;分析其表达与HBV复制水平的相关性。结果免疫组化显示p28GANK在肝癌组织表达水平显著高于其对应癌旁组织(P<0.01)。p28GANK表达水平与患者TNM分期、侵袭转移及HBV-DNA复制水平显著相关(P<0.05),而与患者性别、年龄及血清AFP水平无关(P>0.05)。结论 p28GANK在HBV相关肝细胞癌中表达增强,可能参与HBV-DNA复制,是治疗HBV相关肝癌的重要生物靶点。
Objective To study the clinical significance of p28GANK in the expression of hepatitis B virus (HBV) -related hepatocellular carcinoma (HCC). Methods Hepatocellular carcinoma (HCC) and corresponding paracancerous tissues were collected. Immunohistochemistry was used to detect the expression of p28GANK and its corresponding paracancer tissues. The correlation between HCC expression and clinical parameters was analyzed. Copy level relevance. Results Immunohistochemistry showed that the expression of p28GANK in HCC tissues was significantly higher than that in corresponding paracancerous tissues (P <0.01). The expression level of p28GANK was significantly correlated with TNM staging, invasion and metastasis and HBV-DNA replication level (P <0.05), but not with gender, age and serum AFP level (P> 0.05). Conclusion The expression of p28GANK in HBV-related hepatocellular carcinoma (HCC) may be involved in HBV-DNA replication and is an important bio-target for the treatment of HBV-related HCC.