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目的:研究化浊祛脂方对实验性高脂血症大鼠血脂及血清丙二醛(MDA)、超氧化物歧化酶(SOD)、氧化低密度脂蛋白(oxLDL)的影响。方法:采用高脂饮食喂饲法建立大鼠高脂血症模型,同时灌胃给予化浊祛脂方3g/(kg.d),连续给药90天,并检测总胆固醇(TC)、甘油三酯(TG)、高密度脂蛋白-胆固醇(HDL-C),及血清MDA含量,血清SOD活力和血浆oxLDL浓度。结果:化浊祛脂方能显著降低高脂大鼠血中TC、TG、MDA、oxLDL水平(P<0.01),显著提高HDL-C和SOD活力(P<0.05)。结论:提示本方具有降脂和抗脂质过氧化作用。
Objective: To study the effect of Huazhuo Yuzhi Recipe on blood lipid and malondialdehyde (MDA), superoxide dismutase (SOD), and oxidized low density lipoprotein (oxLDL) in experimental hyperlipidemic rats. METHODS: A rat model of hyperlipidemia was established by high-fat diet, and 3g/(kg.d) of Huazhuo Antilipid was given by intragastric administration for 90 consecutive days. Total cholesterol (TC) and glycerol were measured. Triglycerides (TG), high-density lipoprotein-cholesterol (HDL-C), and serum MDA levels, serum SOD activity, and plasma oxLDL concentrations. RESULTS: Huazhuo Yuzhi significantly reduced the levels of TC, TG, MDA and oxLDL in blood of hyperlipidemic rats (P<0.01), and significantly increased the activity of HDL-C and SOD (P<0.05). Conclusion: It is suggested that this prescription has lipid-lowering and anti-lipid peroxidation effects.