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目的：观察降纤酶对频发的短暂性脑脑缺血发作的疗效。方法：60例频发的TIA患者随机分为降纤酶治疗组130例和低分子右旋糖断＋复方开参＋肠溶阿斯匹林对照组（30例）。结果：治疗组治疗后24小时内及72小时内TLA发作控制率分别为66．6％和96．0％，均明显高于对照组（20％和70％，P＜0．01）。降纤酶治疗后血液粘度及纤维蛋白原明显降低。结论：应用降纤酶对频发的TIA疗效是显著的，且可减少脑梗死的发生率。
Objective: To observe the effect of defibrase on the occurrence of frequent transient ischemic attacks. Methods: Sixty patients with TIA were randomly divided into treatment group (n = 130), dextran treatment group (n = 30) and low molecular weight dextran plus compound prescription plus enteric aspirin control group (n = 30). Results: The control rates of TLA within 24 hours and 72 hours after treatment in treatment group were 66.6% and 96.0%, respectively, which were significantly higher than those in control group (20% and 70%, P <0.01). After defibrase treatment of blood viscosity and fibrinogen significantly reduced. Conclusion: The application of defibrase on the treatment of frequent TIA is significant, and can reduce the incidence of cerebral infarction.