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棉酚对雌性动物以及妇女生殖系统的影响或可能的抗生育作用,国、内外已有所报道,但作为一种节育药物除有效外,必需安全无毒害作用,因此,在深入研究棉酚对女性的抗生育作用时,有必要对其毒性以及有效剂量与致死量的关系进行实验研究,本实验在这方面利用妊娠大白鼠进行了观察。实验动物分为8个剂量组:即100mg/kg、81mg/kg、66 mg/kg、53 mg/kg、43 mg/kg、35 mg/kg、28 mg/kg,23 mg/kg等。于妊娠第1至第5天,各实验组分别按上述剂量每天灌服一次棉酚油悬液,对
Gossypol on female animals and women’s reproductive system or possible anti-fertility effects, both at home and abroad have been reported, but as an in vitro fertilization drugs in addition to effective, safe and non-toxic effects, therefore, in-depth study of gossypol Female anti-fertility, it is necessary to study its toxicity and the relationship between effective dose and lethal dose, the experiment in this regard the use of pregnant rats were observed. The experimental animals were divided into 8 dose groups: 100mg / kg, 81mg / kg, 66mg / kg, 53mg / kg, 43mg / kg, 35mg / kg, 28mg / kg, 23mg / kg and so on. In the first to fifth days of pregnancy, the experimental groups were dosed once a day with the above dose of gossypol oil suspension,