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采用ＬＳＡＢ免疫组化法，对４６例食管癌及３１例贲门癌患者的癌组织进行了ｎｍ２３基因（下简称ｎｍ２３）染色检测。结果显示，食管癌组织染色阳性率明显低于癌旁组织，分化较好的癌组织染色阳性率明显高于分化差的癌组织，原发灶染色阳性率明显高于转移灶，有淋巴结转移的食管癌组织染色阳性率明显低于无转移者。贲门癌中，除有淋巴结转移的贲门癌组织与无淋巴结转移的贲门癌组织染色阳性率差异不显著外，其他相关性同食管癌。两种肿瘤的ｎｍ２３表达情况均与患者的性别、年龄、家族史无明显关系。可见ｎｍ２３在食管癌及贲门癌的发生、发展中所起的作用各有异同
LSAB immunohistochemistry was used to detect nm23 (abbreviated as nm23) staining in 46 cases of esophageal cancer and 31 cases of cardiac cancer. The results showed that the positive staining rate of esophageal cancer tissue was significantly lower than that of paracancerous tissue. The positive staining rate of well-differentiated cancer tissue was significantly higher than that of poorly differentiated cancer tissue. The positive rate of primary foci staining was significantly higher than that of metastatic foci, with lymph node metastasis. The positive rate of esophageal cancer tissue staining was significantly lower than those without metastasis. In cardia cancer, except for the positive rate of lymph node metastasis of cardiac cancer tissue and the absence of lymph node metastasis, there was no significant difference in the positive rate of gastric cardia cancer tissue metastasis. The expression of nm23 in both tumors was not significantly related to the patient’s gender, age, and family history. It can be seen that the roles played by nm23 in the occurrence and development of esophageal and cardiac cancers are similar and different.