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关于血红蛋白基因型和ABO血型是否影响恶性疟原虫感染红细胞形成玫瑰花结的问题,有人认为镰状红细胞携带者(AS基因型)的红细胞失去与恶性疟原虫感染红细胞形成玫瑰花结的能力,从而对恶性疟产生抵抗力;也有实验表明感染原虫的A型或B型红细胞比O型红细胞更易于形成玫瑰花结。本文报告ABO血型和血红蛋白基因型对玫瑰花结形成的影响进行试验的结果。
Regarding the question of whether the hemoglobin genotype and the ABO blood group affect the formation of rosettes in erythrocytes infected with P. falciparum, it has been suggested that the erythrocytes of sickle cell carriers (AS genotypes) lose the ability to form rosettes with erythrocytes infected with P. falciparum Resistant to falciparum malaria; experiments have also shown that either type A or type B erythrocytes infected with protozoa are more likely to form rosettes than type 0 erythrocytes. This article reports the results of the ABO blood group and hemoglobin genotypes on the rosettes.