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心血管疾病仍然是CKD患者主要的死亡原因。血管功能障碍,表现为内皮功能障碍和动脉硬化,是一种重要的非传统心血管危险因素,肾功能衰竭过程早期即可发生,能够预测未来心血管事件。在轻度CKD,内皮功能障碍与内皮修复机制缺陷同时存在:骨髓来源的内皮祖细胞水平低,循环血管生成细胞的迁移功能下降。最近发现,循环成骨祖细胞的数量增多与血管钙化和动脉硬化有关。因为发现血管内皮功能障碍在包括动脉硬化的心血管并发症的发病机制中起着关键作用,治疗内
Cardiovascular disease remains the leading cause of death in CKD patients. Vascular dysfunction, manifested as endothelial dysfunction and atherosclerosis, is an important non-traditional cardiovascular risk factor that occurs early in the course of renal failure and can predict future cardiovascular events. In mild CKD, endothelial dysfunction and endothelial repair defects exist: the low level of bone marrow-derived endothelial progenitor cells, circulating migration of angiogenic cells decreased. Recently, it has been found that the increased number of circulating osteogenic progenitor cells is associated with vascular calcification and arteriosclerosis. Because vascular endothelial dysfunction has been found to play a key role in the pathogenesis of cardiovascular complications including atherosclerosis,