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目的观察三维适形放射治疗非小细胞肺癌(NSCLC)的近期疗效与毒副作用。方法13例鳞癌、9例腺癌、3例腺鳞癌,其中2例肺鳞癌为手术后、化疗后局部复发。24例患者以前未做过放疗。肿瘤影像直径在4～8cm之间,适形野3～6个;肿瘤剂量48～66Gy;8～16分次,8～28d完成。锁骨上区淋巴结转移用6MV-X线加12MeV电子线常规分割放疗,剂量65～70Gy,7周左右完成。结果24例患者1、2年疗效观察。8例完全缓解(CR)、10例部分缓解(PR)、2例稳定(NC)、4例进展(PD),总有效率(CR+PR)为75.0%(18/24),1、2年生存率分别为70.8%、45.8%。结论三维适形放射治疗非小细胞肺癌近期疗效较好,毒副反应小,严重并发症发生率低。
Objective To observe the short-term curative effect and side effects of three-dimensional conformal radiotherapy in non-small cell lung cancer (NSCLC). Methods Thirteen patients with squamous cell carcinoma, 9 adenocarcinoma and 3 adenosquamous carcinoma were included in this study. Two cases of squamous cell carcinoma of the lung were locally recurrent after chemotherapy and chemotherapy. Twenty-four patients had not previously had radiotherapy. Tumor imaging diameter between 4 ~ 8cm, conformal field 3 to 6; tumor dose 48 ~ 66Gy; 8 ~ 16 times, 8 ~ 28d completed. Supraclavicular lymph node metastasis with 6MV-X line plus 12MeV electronic conventional radiotherapy, dose 65 ~ 70Gy, 7 weeks to complete. Results 24 cases of patients 1, 2 years efficacy. 8 cases of complete remission (CR), 10 cases of partial remission (PR), 2 cases of stable (NC), 4 cases of progression (PD), the total effective rate (CR + PR) was 75.0% The annual survival rates were 70.8% and 45.8% respectively. Conclusion Three-dimensional conformal radiotherapy for non-small cell lung cancer has better curative effect, less side effects and lower incidence of serious complications.