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目的采用Meta分析方法评价D-二聚体(D-D)对卵巢癌的诊断价值。方法计算机检索Pub Med数据库、万方数据库、中国知网数据库、维普数据库,检索年限从2006年7月~2016年7月,收集关于D-D对卵巢癌诊断的相关研究文献。由2位研究者根据纳入与排除标准筛选文献、提取资料,应用Revman5.3版软件使用QUADAS-2条目工具评价纳入研究质量,采用Meta-Disc 1.4版软件进行Meta分析。结果 10篇文献符合纳入标准入组本系统评价。Meta分析的结果显示:D-D的合并诊断比值比为12.692[95%可信区间(CI):6.817,23.628];受试者工作特征曲线(SROC)曲线下面积(AUC)为0.8541,Q指数为0.7851。亚组分析结果显示疗前检测D-D组合并诊断比值比为27.541(95%可信区间:15.586,48.666);SROC AUC为AUC=0.9080;Q指数为0.8399。结论疗前D-D水平对卵巢癌具有较高的临床诊断价值。
Objective To evaluate the diagnostic value of D-dimer (D-D) in ovarian cancer by Meta-analysis. Methods The Pub Med database, Wanfang database, CNKI database and VIP database were searched by computer. The searching period was from July 2006 to July 2016, and the relevant research literature on the diagnosis of ovarian cancer by D-D was collected. Two investigators screened the literature based on inclusion and exclusion criteria, extracted data, evaluated the inclusion of research using the RevMan version 5.3 software using the QUADAS-2 entry tool, and Meta-analysis using the Meta-Disc version 1.4 software. Results 10 articles met the inclusion criteria for inclusion in the systematic review. Meta-analysis showed that DD was 12.692 [95% confidence interval (CI): 6.817, 23.628]; area under the receiver operating characteristic curve (SROC) curve was 0.8541 and Q index was 0.7851. The subgroup analysis showed that the ratio of diagnostic D-D was 27.541 (95% confidence interval: 15.586,48.666). The AUC of SROC was AUC = 0.9080 and the Q-index was 0.8399. Conclusion The pre-treatment D-D level has a high clinical diagnostic value for ovarian cancer.