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目的探讨三阴性乳腺癌的临床病理特征、治疗方法、转移情况与预后的关系。方法回顾性分析138例三阴性乳腺癌患者临床、病理及随访资料。结果三阴性乳腺癌患者3、5年无瘤生存率与绝经前、后发病,原发病灶大小,是否保乳,病理类型,化疗方案均无关(均P>0.05);与临床分期、淋巴结转移、病理分级均有相关性(均P<0.05)。患者的3年无瘤生存率与家族史、与放疗均有相关性(均P<0.05)。结论淋巴结转移、临床分期、病理分级均为影响预后的重要因素;保乳与否及常用的化疗方案与预后均无关;放疗可提高3年无瘤生存率,但不能提高5年无瘤生存率。术后转移者预后差,生存期<2年。
Objective To investigate the clinicopathological features, treatment, metastasis and prognosis of triple negative breast cancer. Methods The clinical, pathological and follow-up data of 138 patients with triple-negative breast cancer were retrospectively analyzed. Results The 3-year and 5-year disease-free survival rates of triple-negative breast cancer patients had no correlation with the incidence of premenopausal or postmenopausal women, primary tumor size, breast-conserving milk, pathological type and chemotherapy regimen (all P> 0.05) , Pathological grade has correlation (all P <0.05). The 3-year disease-free survival was related to family history and radiotherapy (all P <0.05). Conclusion Lymph node metastasis, clinical stage and pathological grading are both important prognostic factors. There is no correlation between breast-conserving therapy and commonly used chemotherapy regimen and prognosis. Radiotherapy can improve the 3-year disease-free survival rate but can not increase 5-year disease-free survival rate . Postoperative metastasis poor prognosis, survival <2 years.