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目的:考察注射用雷替曲塞用0.9%氯化钠注射液或5%葡萄糖注射液溶解稀释后输液的稳定性。方法:模拟临床实际情况,分别考察雷替曲塞输液在不同温度下(4℃冰箱内、25℃室内不避光和37℃室内不避光)24 h内的外观、不溶性微粒、pH值和含量的变化。结果:雷替曲塞输液在不同温度下24 h内的外观和pH值均无明显改变,不溶性微粒符合药典相关规定,雷替曲塞相对初始含量的变化范围在93.9%~100.7%之间。结论:在临床常见情况下,雷替曲塞输液在24 h内的稳定性良好,不必现配现用。
OBJECTIVE: To investigate the stability of dilute transfusion solution after injection of raltitrexed with 0.9% sodium chloride injection or 5% glucose injection. Methods: To simulate the clinical situation, the effects of raltitrexed infusion on the appearance of insoluble particles, pH value and pH value within 24 h at different temperatures (4 ℃ refrigerator, 25 ℃ indoor without light and 37 ℃ indoor without light) Changes in content. Results: The appearance and pH value of raltitrexed infusion did not change significantly at different temperatures for 24 h. The insoluble particles were in accordance with the pharmacopoeia. The relative initial content of raltitrexed ranged from 93.9% to 100.7%. CONCLUSION: In the most common clinical cases, the stability of raltitrexed infusion within 24 h is good, and it is not necessary to find out the current use.