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肾小球的花生四烯酸(AA)代谢变化,在肾毒性肾炎实验模型中已被证实。离体肾小球合成的凝血素A_2(TxA_2)的增加可促使肾脏血流动力学发生变化。本文旨在验证那些确无白细胞浸润和血小板沉积的肾小球病模型中是否也有肾小球AA代谢的变化;确定AA代谢变化与蛋白尿之间的连系;并探索离体肾小球中前列腺素的变化途径究竟是实验假象还是反映活体的真实改变。对小鼠单独静脉注入阿霉素制成肾小球损伤模
Glomerular arachidonic acid (AA) metabolic changes in nephrotoxic nephritis experimental model has been confirmed. In vitro glomerular synthesis of hemagglutinin A 2 (TxA 2) increased renal hemodynamics can lead to changes. This article aims to verify whether those who do not leukocyte infiltration and platelet deposition in the glomerular disease model also have changes in the metabolism of glomerular AA; to determine the relationship between AA metabolic changes and proteinuria; and explore the ex vivo glomerular Prostaglandin changes in the way whether the experimental illusion or reflect the real changes in living. Doxorubicin was intravenously injected into mice to make glomerular injury model