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细胞内的细菌弱毒株因其能模仿胞内病原体的生活方式及能在接种个体中复制或者至少持续存在一段时间 ,从而成为激发 T细胞介导免疫的理想候选物。作者利用弱毒胞内菌 ,建立了一些将亚单位疫苗有效地送递给巨噬细胞和树突状细胞等专职抗原提呈细胞的系统。 使用不同的菌株和
Weak bacterial strains of cells are ideal candidates for stimulating T cell-mediated immunity because they replicate the life-form of intracellular pathogens and replicate in the vaccinated individuals or persist for at least a period of time. Using attenuated intracellular bacteria, the authors established several systems that efficiently deliver subunit vaccines to specialized antigen-presenting cells such as macrophages and dendritic cells. Use different strains and