论文部分内容阅读
目的探讨神经生长因子治疗新生儿缺氧缺血性脑病的机制及有效方案。方法选择我院2004年3月～2007年3月本院新生儿病房生后3天内符合全国HIE诊断标准13J的患儿82例随机分为对照组和观察组,分别于住院当天、住院3天和住院7天分别进行血浆血管内皮生长因子、CT检查及B超检查;以及进行NBNA20项行为测定和神经精神发育随访。结果观察组与对照组治疗后显示肌张力、吸吮反射、拥抱反射和意识恢复时间比较有显著差异。观察组与对照组患儿颅脑B超住院3天比较脑水肿指标有极显著差异。观察组、对照组患儿血浆血管内皮生长因子与同组0天比较有显著差异。观察组与对照组小儿颅脑CT异常率住院3天、住院7天比较有显著差异。观察组与对照组小儿住院7天、住院28天NANB评分结果比较有统计学意义。6个月时随访,观察组与对照组小儿精神运动发育商有显著差异。结论外源性神经生长因子可以使受损的神经元得以修复,而在新生儿缺血缺氧性脑病的早期由于血管内皮生长因子的水平较高,不宜使用。
Objective To investigate the mechanism of NGF therapy in neonatal hypoxic-ischemic encephalopathy and its efficacy. Methods Eighty-two children who met the national HIE diagnostic criteria 13J within 3 days after birth in our hospital from March 2004 to March 2007 were randomly divided into control group and observation group. The patients were admitted to hospital for three days And hospitalized for 7 days respectively, vascular endothelial growth factor, CT examination and B-ultrasound; and conduct NBNA20 behavior and neuropsychiatric development follow-up. Results The observation group and the control group showed significant differences in muscle tone, sucking reflex, embracing reflex and consciousness recovery time after treatment. Observation group and control group children with brain B-hospital over three days were significantly different indicators of cerebral edema. There was a significant difference between the observation group and the control group on the level of plasma vascular endothelial growth factor in comparison with the 0-day group. The observation group and control group children with abnormal brain CT rate of hospitalization for 3 days, 7 days were significantly different. The observation group and control group children hospitalized 7 days, 28 days hospitalization NANB score results were statistically significant. At 6 months follow-up, there was a significant difference between the observation group and the control group in children’s psychomotor development. Conclusion Exogenous nerve growth factor can repair damaged neurons, but should not be used in the early stage of neonatal hypoxic-ischemic encephalopathy due to the high level of vascular endothelial growth factor.