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应用聚合酶链反应研究了１００例北京地区正常汉族人载脂蛋白Ｂ基因４个位点的多态性分布情况。在这一群体中，载脂蛋白Ｂ信号肽序列以Ｉｎｓ等位基因占优势，其频率达０．７６５，而Ｄｅｌ等位基因相对少见（０．２３５）．ＸｂａＩ和ＥｃｏＲＩ酶切位点以Ｘ－和Ｅ＋等位基因占绝大多数，其频率分别为０．９７５和０．９６，Ｘ＋和Ｅ－等位基因十分少见，其频率仅为０．０２５和０．０４．对可变数目串联重复序列共检出１０种等位基因（３＇β２９～３＇β４９），其中以３＇β３７等位基因最为常见，其次为３＇β３９等位基因，两者检出率达６８％。结果表明，北京地区汉族人的载脂蛋白Ｂ基因多态性分布与不同种族间存在明显差异，与白种人的差异尤为显著。揭示人类不同种族有其自己的遗传特点。
Polymerase chain reaction was used to study the polymorphism distribution of four apolipoprotein B genes in 100 Han normal population in Beijing. In this population, the apolipoprotein B signal peptide sequence predominates with the Ins allele at a frequency of 0.765 and the Del allele is relatively rare (0.235). The XbaI and EcoRI restriction sites have a predominance of X- and E + alleles at frequencies of 0.975 and 0.96, respectively, and the X + and E-alleles are rare with frequencies of only 0.025 and 0.04. A total of 10 alleles (3’β29 ~ 3’β49) were detected in a variable number of tandem repeats, of which the 3’β37 allele was the most common, followed by the 3’β39 allele, the detection rate of both Up to 68%. The results showed that there was a significant difference between the distribution of apolipoprotein B gene polymorphism and ethnicity in Han nationality in Beijing, especially among white people. Revealing that people of different races have their own genetic traits.