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在考虑有机汞特别是甲基汞的毒性时,生物体内汞的半减期作为体内蓄积,排泄的指标具有重要意义,近年来引起人们反复讨论。根据迄今为止的报告,Birke等人以食污染鱼较多者的血液与头发进行测定的半减期约为70天,Aberg等人测得3名成年男子的甲基汞半减期为70～74天(全身),Clarkson及Shapiro测定的半减期为69天,椿研究新泻水俣病的病例测定的半减期为40～120夭(平均65夭)。武内提出,就水俣病而言,重要的不是全身半减期,而是在脏器特别是在脑的半减期,对于水俣病死亡者实际测定的结果约为230天。不久以前,Al-Shahristani等人发表了关于1971～72年在伊拉克发生的甲基汞农药处理小麦引起的大量中毒事件中48名中毒者头发的汞半减期的报告(原载Arch. Environ. Health, 28(6), 342,1974)。头发汞值的测定步骤如下:将10～50根头发从根部2毫米处切断,按1厘米的
In considering the toxicity of organic mercury, especially methylmercury, half-life reduction of mercury in the body as an indicator of accumulation and excretion in vivo is of great significance and has been repeatedly discussed in recent years. According to the reports so far, Birke et al. Measured the blood and hair of contaminated fish more than 70 days. Aberg et al. Measured the half-life of methylmercury in three adult men as 70% At 74 days (whole body), the half-reduction period measured by Clarkson and Shapiro was 69 days. The half-reduction period for the Niigata Minamata test was 40 to 120 days (mean, 65 days). Takeuchi suggested that in the case of Minamati disease, it is not the half-life of the body that is important but the half-life of the organ, especially in the brain. The actual result for the death of Minamata disease is about 230 days. Not long ago, Al-Shahristani et al. Reported on the half-reduction of mercury in the hair of 48 poisoned persons in a large number of poisonings caused by methylmercury pesticide-treated wheat in Iraq in 1971-72 (previously Arch. Environ. Health, 28 (6), 342, 1974). Hair mercury determination steps are as follows: the 10 to 50 hair root 2 mm cut off, according to 1 cm