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为探讨肺内调节肽对支气管上皮细胞 (bronchialepithelialcells ,BECs)分泌功能的影响 ,实验观察了兔BECs在未受应激与臭氧应激两种条件下白细胞介素 (interleukin ,ILs)的分泌。结果发现 :血管活性肠肽 (vasoactiveintestinalpeptide ,VIP)对未受应激BECs存在抑制作用 ,并使臭氧应激BECs分泌ILs下降 ;表皮生长因子 (epidermalgrowthfactor,EGF)使未受应激BECsIL 1、IL 8分泌增加 ,使臭氧应激的BECsILs分泌降低 ;内皮素 1(endothelin 1,ET 1)、降钙素基因相关肽 (calcitoningene relatedpeptide ,CGRP)可使未受应激的BECs分泌ILs增加 ,CGRP还可使臭氧应激的BECsILs分泌增加。结果提示 :肺内调节肽可调控BECsILs的分泌 ,在调控气道炎症损伤信号传递方面具有一定的作用
To investigate the effect of pulmonary regulatory peptides on secretion of bronchial epithelial cells (BECs), we observed the secretion of interleukin (IL) in rabbit BECs under stress and ozone stress. The results showed that vasoactive intestinal peptide (VIP) had no inhibitory effect on unstressed BECs and decreased ILs secreted by ozone stress BECs. Epidermal growth factor (EGF) decreased the expression of IL-1, IL-8 Secretion of BECsILs in ozone stress is decreased; endothelin 1 (ET 1) and calcitonin gene related peptide (CGRP) can increase the secretion of ILs in unstressed BECs, and CGRP can also increase Ozone stress BECsILs secretion increased. The results suggest that the pulmonary regulatory peptides can regulate the secretion of BECsILs and play a role in the regulation of airway inflammation injury signaling