论文部分内容阅读
近年来，多项研究结果显示：微小RNAs（miRNAs）在胰腺组织、胰腺癌细胞和胰腺癌耐药细胞中具有差异性表达，且miRNAs可通过对下游靶基因的作用改变胰腺癌细胞对化疗药物敏感性。肿瘤的耐药分子机制错综复杂，在胰腺癌耐药中，miRNAs可以通过影响胰腺癌细胞中上皮-间质转化、DNA的损伤和修复、下游信号通路、非编码RNA、相关编码基因、胰腺癌干细胞等机制介导胰腺癌耐药。因此，对胰腺癌耐药机制及相关miRNAs的探讨有助于寻找新的抗耐药治疗方法，笔者通过对参与调控胰腺癌化疗药物耐药的外泌体miRNAs进行总结，为临床治疗胰腺癌提供理论支持和寻找新靶向治疗方案。“,”In recent years, many researchs have found that microRNA (miRNAs) has differential expression in pancreatic tissues, pancreatic cancer cells and drug-resistant pancreatic cancer cells, and miRNAs can change the sensitivity of pancreatic cancer cells to chemotherapy drugs by acting on downstream target genes.The molecular mechanism of drug resistance in tumors is complex. In the drug-resistance of pancreatic cancer, miRNAs can mediate drug resistance in pancreatic cancer cells by affecting epithelial-mesenchymal transformation, DNA damage and repair, downstream signaling pathways, non-coding RNA, related coding genes, pancreatic cancer stem cells and other mechanisms. Therefore, the investigation of drug resistance mechanism and related miRNAs in pancreatic cancer will help to find new anti-drug resistance treatment methods. The authors summarize exosome miRNAs invloved in regulating chemoresistance in pancreatic cancer, in order to provide theoretical support for clinical treatment and find new targeted therapy of pancreatic cancer.