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目的 对恶性肿瘤患者的血小板活化状态抗凝及纤溶部分指标进行检测 ,探讨其血栓前状态生物指标的变化。方法 采用酶联免疫法和发色底物法检测肿瘤患者 5 0例 ,正常人 30例的活化血小板α颗粒膜蛋白 (GMP 14 0 )及血浆蛋白 (PC) ,组织型纤溶酶原激活物 (t PA)及其抑制物 (PAI)含量。结果 肿瘤患者GMP 14 0、PC、t PA量显著增高 (P <0 .0 5 )PAI与正常人相近 ,(P >0 .0 5 )。结论 提示恶性肿瘤患者存在着血小板活化功能、凝血和纤溶活性增强。
Objective To detect the anticoagulant and fibrinolytic markers of platelet activation in patients with malignant tumors, and to explore the changes in the biological indicators of prethrombotic state. METHODS: Enzyme-linked immunosorbent assay (ELISA) and chromogenic substrate method were used to detect 50 patients with tumor and 30 normal controls. Activated platelet alpha granule membrane protein (GMP 14 0) and plasma protein (PC), tissue plasminogen activator (t PA) and its inhibitor (PAI) content. Results The GMP 14 0, PC, and t PA levels in tumor patients were significantly higher (P < 0.05). PAI was similar to normal people (P > 0.05). Conclusion It is suggested that patients with malignant tumors have platelet activation, increased coagulation and fibrinolytic activity.