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目的 观察介入方法综合治疗高危大肠癌的远期疗效。方法 大肠癌根治术及再次根治术 ;术中门脉置管及手术前后选择性肝动脉 ,肠系膜上或肠系膜下动脉 ,髂内动脉或腹壁下动脉插管化疗 ;术后腹腔灌注化疗 ;全身辅助化疗 ;局部辅助放疗 ;中医中药和免疫治疗等有机综合治疗方法随机性治疗 2 2例高危大肠癌 ,并与常规综合治疗 2 5例对照 ,观察其 1.5年及 2 .5年无瘤生存率。结果 治疗组 1.5年无瘤生存率 90 .9% ,对照组 72 .0 % ,两者比较无显著性差异 (P >0 .0 5 ) ,治疗组 2 .5年无瘤生存率 76 .9% ,对照组为 42 .9% ,两者比较差异显著 (P <0 .0 5 )。治疗组的毒副反应及并发症均较对照组减轻。结论 有机溶入介入疗法及中医中药的综合治疗方法 ,可提高高危大肠癌病人 1.5年及2 .5年无瘤生存率 ,且治疗的毒副反应及并发症均较轻。
Objective To observe the long-term effect of interventional therapy in the treatment of high-risk colorectal cancer. Methods of radical resection of colorectal cancer and radical surgery; intraoperative portal catheter and preoperative and postoperative selective hepatic artery, superior mesenteric or inferior mesenteric artery, internal iliac artery or abdominal artery arterial chemotherapy; intraperitoneal chemotherapy; systemic assistance Chemotherapy; local adjuvant radiotherapy; traditional Chinese medicine and immunotherapy and other organic integrated therapy Randomized treatment of 22 cases of high-risk colorectal cancer, and conventional comprehensive treatment of 25 cases of control, observed 1.5 years and 2.5 years of tumor-free survival. Results In the treatment group, the tumor-free survival rate at 1.5 years was 90.9% and in the control group 72.0%, there was no significant difference between the two groups (P> 0.05). The 2.5-year disease-free survival rate in the treatment group was 76.9 %, While the control group was 42.9%, the difference was significant (P <0.05). Toxic side effects and complications of the treatment group were alleviated compared with the control group. Conclusions The organic dissolving interventional therapy and the comprehensive treatment of traditional Chinese medicine can improve the tumor-free survival rate of 1.5 and 2.5 years in patients with high-risk colorectal cancer, and the side effects and complications of treatment are mild.