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了解ＨＢＶ前Ｃ区１８９６位点变异与乙型肝炎病毒感染者肝功能损害程度的关系。方法：用ＰＣＲ技术，通过改变引物３’端的方法，检测ＨＢＶ感染者的前Ｃ区第１８９６位点变异株。结果：１０５例ＨＥＶ感染者中的ＨＢＶ前Ｃ区１８９６位点变异株总检出率为５６．２％；男性与女性患者的检出率分别为５７．０％与５００％；≤３０岁组，３１－５９岁组，≥６０岁年龄组的检率分别为６０．０％，５６．６％，２８．６％；无黄疸组，轻～中度黄疸组，重度黄疸组的检出率分别为５３．２％，６５．１％，４０．０％；在ＨＢＶ携带者、慢性肝炎（包括轻、中、重庆），重症肝炎及肝硬化患者中的检出率分别为６０．０％，５７．４％，３３．３％，７０．０％。结论：ＨＢＶ前Ｃ区１８９６位点突变株广泛存在于ＨＢＶ感染者中，而且其检出率与患者性别、年龄、ＨＢＶ感染时间长短及肝功能损害程度并无明显联系。
To understand the relationship between HBV pre-C1896 mutation and the degree of liver damage in patients with hepatitis B virus infection. Methods: The mutation of 1896 site in pre-C region of HBV infected patients was detected by PCR method by changing the 3 ’end of primer. Results: The overall detection rate of 1896 loci in pre-HBV C region of 105 cases of HEV was 56.2%. The detection rates of male and female patients were 57.0% and 500% respectively. , 31-59 years old group, ≥60 years old group were 60.0%, 56.6%, 28.6% respectively; The detection rate of no jaundice group, mild to moderate jaundice group and severe jaundice group Respectively, 53.2%, 65.1% and 40.0% respectively. The detection rates of HBV carriers, chronic hepatitis (including mild, moderate and severe), severe hepatitis and cirrhosis patients were 60.0% , 57.4%, 33.3%, 70.0%. CONCLUSION: The 1896 site mutation in pre-HBV region of HBV is widely found in HBV infected persons. The detection rate is not related to the patient’s sex, age, duration of HBV infection and extent of liver damage.