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自然杀伤(NK)细胞是不需预先致敏又无组织相容限制性,就能溶解靶细胞的一类淋巴细胞亚群。较早的研究曾提出,结核病患者胸腔积液中的单个核细胞(PEMNC)NK 活性增高。本研究为了判定和比较结核性PEMNC 和外周血单个核细胞(PBMNC)的细胞毒性和免疫活性,检测加PPD(纯蛋白衍生物)培养前后这两类细胞IL-2、IFN-α、β和γ,的产生,还测定Leull~+(CD16~+)细胞IL-2受体的数量,并对诱导与效应期的细胞毒细胞的表面进行了分析。取肺结核患者(38—81岁,男9、女2例)的
Natural killer (NK) cells are a subset of lymphoid cells that can lyse target cells without pre-sensitizing and histocompatibility-limiting. Earlier studies have suggested that NK activity of mononuclear cells (PEMNC) in pleural effusion of tuberculosis patients is increased. In this study, in order to determine and compare the cytotoxicity and immunological activity of tuberculous PEMNC and peripheral blood mononuclear cells (PBMNC), the levels of IL-2, IFN-a, beta and The number of IL-2 receptors in Leull ~ + (CD16 ~ +) cells was also measured and the surface of induced and effector cytotoxic cells was analyzed. Take tuberculosis patients (38-81 years old, 9 men and 2 women)