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目的探讨中等剂量地塞米松与甲强龙冲击治疗全身型重症肌无力的疗效。方法选取2013年4月至2016年4月期间收治的全身型重症肌无力患者30例,根据患者治疗方法的不同分为两组,每组各15例,a组患者予以中等剂量地塞米松治疗,b组患者予以大剂量甲基强龙治疗,观察两组患者治疗4~10d的不良评分及3个月内不良反应、治疗效果。结果两组患者治疗1个月的效果,P>0.05;治疗3个月a组的痊愈和基本痊愈高于b组,P>0.05;4~10d的不良评分a组为(0.76±1.03)分,b组为(0.71±1.02)分,差异不明显(P<0.05);a组3个月内出现不良反应均较b组低,仅高血压、体重增及感染发生率,P<0.05。结论中等剂量的地塞米松与大剂量的甲强龙冲击治疗的效果相同,但治疗后高血压、体重增及感染的不良反应率均明显低于甲强龙冲击治疗。
Objective To investigate the effect of moderate dose dexamethasone and methylprednisolone on patients with systemic myasthenia gravis. Methods Thirty patients with systemic myasthenia gravis treated in our hospital from April 2013 to April 2016 were divided into two groups with 15 patients in each group. Patients in group a were treated with moderate dose of dexamethasone , b group were given high-dose methylprednisolone treatment, two groups of patients treated 4 ~ 10d bad score and 3 months of adverse reactions, the treatment effect. Results The effect of treatment for one month in both groups was significant (P> 0.05). The cure and basic recovery of group A at 3 months were higher than that of group b (P> 0.05), and the score of group A at 4 ~ 10 days was (0.76 ± 1.03) (0.71 ± 1.02) in group b, the difference was insignificant (P <0.05). In group a, the adverse reaction within 3 months was lower than that of group b, only the incidence of hypertension, weight gain and infection, P <0.05. Conclusions The moderate dose of dexamethasone has the same effect with high dose of methylprednisolone, but the adverse reaction rate of hypertension, weight gain and infection after treatment is significantly lower than that of methylprednisolone.