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目的对潮州地区先天性甲状腺功能减低症(CH)的筛查和随访结果进行分析。方法测定生后72h新生儿足跟血滤纸干血片的促甲状腺激素(TSH),TSH大于切值者为筛查阳性,召回测血清FT4和TSH确诊。用左甲状腺素钠替代治疗,并定期随访。结果共筛查新生儿32 682例,检出阳性患儿11例,发病率为1/2971。经治疗,身高和智力发育平均水平达到正常。结论新生儿筛查是CH早期诊断的唯一方法,筛查检出的CH患儿经替代治疗后,智能和体格发育可达正常,治疗越早,效果越好。
Objective To analyze the screening and follow-up results of congenital hypothyroidism (CH) in Chaozhou area. Methods Thyroid stimulating hormone (TSH) was measured at 72h after birth in the hematopharynx of the heel hematocrit. Serum levels of TSH greater than the cut-off value were positive for screening. The patients were recalled for the determination of serum FT4 and TSH. With levothyroxine replacement therapy, and regular follow-up. Results A total of 32 682 newborns were screened, and 11 positive children were detected with a prevalence of 1/2971. After treatment, the average height and mental development to normal. Conclusion Neonatal screening is the only method for the early diagnosis of CH. The CH children detected by screening showed normal intelligence and physical development after treatment. The earlier the treatment, the better the effect.