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目的探讨中性粒细胞明胶酶相关脂质运载蛋白(NGAL)检测对子痫前期的意义。方法选取2015年7-12月在该院产科住院的子痫前期患者40例,其中轻度期13例(轻度子痫前期组),重度期27例(重度子痫前期组),另选择40例健康孕妇作为对照组。采用ELISA法分别检测3组孕妇血清、脐血NGAL数值水平。同时对患者的血尿常规、肝肾功能、24 h尿蛋白进行比较。应用SPSS19.0进行统计学分析。结果子痫前期组与对照组血清NGAL数值比较有显著性差异(P<0.05)。子痫前期组与对照组胎儿脐血NGAL数值比较有显著性差异(P<0.05)。子痫前期患者血清NGAL含量与患者血压及24 h尿蛋白呈高度正相关性。结论血清NGAL水平在子痫前期患者中升高,并与疾病的严重程度呈正相关。
Objective To investigate the significance of detection of neutrophil gelatinase-associated lipocalin (NGAL) in preeclampsia. Methods Forty patients with preeclampsia hospitalized in the hospital from July to December in 2015 were selected, including 13 mild cases (mild preeclampsia group), 27 severe cases (severe preeclampsia group) and another Forty healthy pregnant women served as control group. The levels of serum and cord blood NGAL in 3 groups of pregnant women were detected by ELISA. At the same time, hematuria routine, liver and kidney function, 24 h urinary protein were compared. SPSS19.0 was used for statistical analysis. Results There was a significant difference in serum NGAL between preeclampsia group and control group (P <0.05). There were significant differences in NGAL values of umbilical cord blood between preeclampsia group and control group (P <0.05). Serum NGAL levels in patients with preeclampsia were positively correlated with patients’ blood pressure and 24-hour urine protein. Conclusion Serum NGAL levels are elevated in patients with preeclampsia and are positively correlated with the severity of the disease.