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变形链球菌与龋病的关系已成为研究龋病病因和预防的重要课题之一。变形链球菌能利用蔗糖合成非水溶性细胞外葡聚糖,粘附于牙齿表面,成为菌斑的主要组成,并能使糖类发酵产酸,破坏牙体组织。 Bratthall和Perch先后根据变形链球菌菌株所含的特异抗原,把变形链球菌分为7个血清型。Bratthall首先把类似变形链球菌菌株的全细胞热盐酸提取物,用琼脂扩散法分析其特异抗原存在情况,发现由仓鼠所分离的菌株3720和由大鼠所分离的菌株FA-1各含有特异抗原,即命名a和b抗原;又从人类所分离的5株菌株,得另一特异抗原,命名
The relationship between Streptococcus mutans and dental caries has become one of the important topics for studying the etiology and prevention of dental caries. Streptococcus mutans can use sucrose to synthesize water-insoluble extracellular dextran, which adheres to the tooth surface and becomes the main component of plaque. It can ferment sugar to produce acid and destroy tooth tissue. Bratthall and Perch successively classified Streptococcus mutans into seven serotypes based on the specific antigens contained in the mutans Streptococcus strains. Bratthall first whole-cell hot-hydrochloric acid extract similar to Streptococcus mutans was analyzed by agar diffusion method for the presence of specific antigens. It was found that strain 3720 isolated from hamster and strain FA-1 isolated from rat each contained a specific antigen , That is named a and b antigens; and from human isolated five strains, have another specific antigen, named