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普罗布可(Probucol)作用机理Ku0等经过33个月研究发现,单独饮食疗法使总胆固醇下降7%;饮食疗法+普罗布可使之下降20.5%;饮食疗法+普罗布可+考来替泊(Colestipol)则使之下降45.1%。44例高胆固醇血症,经考来替泊+普罗布可治疗后,总胆固醇下降48.5%,LDL胆固醇下降53.3%。随后研究证明,普罗布可加速外周组织(包括病变动脉壁)胆固醇清除。Itakura等证明,普罗布可使外周组织(如脾、脑)载脂蛋白E(apo E)增加;apo E则可介导外周组织胆固醇移向肝脏,从而分解、消除。普罗布可对粥样硬化损害的影响动物
Probucol Mechanism After 30 months of study, Ku0 et al found that diet alone decreased total cholesterol by 7%, diet + probucol decreased by 20.5%, and diet + probucol + Colestipol Then make it down 45.1%. Forty - four patients with hypercholesterolemia experienced a 48.5% reduction in total cholesterol and a 53.3% decrease in LDL cholesterol after treatment with testosterol + probucol. Subsequent studies have shown that probucol accelerates cholesterol clearance in peripheral tissues, including the diseased artery wall. Itakura et al demonstrated that probucol increased apolipoprotein E (apo E) in peripheral tissues (such as spleen and brain) and that apo E mediated the migration of peripheral cholesterol into the liver and thus decomposed and eliminated. Probucol Effects on Atherosclerosis Damage Animals