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PAF 血小板活化因子(1,PAF)是具有很强活性的磷脂,它由多种类型的细胞(如嗜碱粒细胞、巨噬细胞、单核细胞、血小板、肥大细胞和中性粒细胞)产生或活化。其结构经测定为1-O-十六烷基/十八烷基-2-O-乙酰-sn-甘油基-3-磷酸胆碱。 PAF与多种生物活性及途径有关,是多种生理过程的重要介质之一,包括血栓形成、过敏反应、内毒素血症休克、眼疾、胃溃疡、移植物排斥、卵子植入和哮喘等。有足够的证据证明PAF在炎症中起着重要作用。PAF是诱导血管通透性增加和胸
PAF Platelet Activation Factor (1, PAF) is a potent phospholipid that is produced by many cell types such as basophils, macrophages, monocytes, platelets, mast cells, and neutrophils Or activated. Its structure was determined to be 1-O-hexadecyl / octadecyl-2-O-acetyl-sn-glycero-3-phosphocholine. PAF is involved in a variety of biological activities and pathways and is one of the most important mediators of various physiological processes including thrombosis, allergic reactions, endotoxic shock shock, eye diseases, gastric ulcer, graft rejection, egg implantation and asthma. There is sufficient evidence that PAF plays an important role in inflammation. PAF is induced by increased vascular permeability and chest