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在畜牧业方面抗菌药物的应用已引起了抗生素耐药细菌的迅速增加和人们的广泛研究,但很少有人知道在水产养殖方面抗生素耐药细菌蔓延的情况。池养鲇鱼是美国的主要养殖水产,据估计每年因感染嗜水氧单孢菌(Aeromanas hydrophila,也是人类的机会致病菌)致病而遭受不少于10％的经济损失。FDA早已批准用土霉素防治鲇鱼病害。为考察使用土霉素之后抗生素耐药细菌发展的情况,作者研究:① OTc~r和Tc~r在氯单孢菌属中存在的范围;②Tc~r决定子(det-
The use of antimicrobials in livestock husbandry has led to a rapid increase in antibiotic-resistant bacteria and extensive research on humans, but few people know about the spread of antibiotic-resistant bacteria in aquaculture. Pond-raising mullet, the main cultured aquaculture in the United States, is estimated to suffer an annual economic loss of less than 10% due to pathogen infection by Aeromanas hydrophila, also a human opportunistic pathogen. FDA has long approved the use of oxytetracycline to prevent catfish disease. To examine the development of antibiotic-resistant bacteria following oxytetracycline, the authors studied: (1) the range of OTc-r and Tc-r present in Chloromonospora; (2) the Tc-r determinant (det-