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目的:探讨地诺前列酮(欣普贝生)用于足月胎膜早破计划分娩的有效性及安全性。方法:选取足月胎膜早破具备计划分娩指征,宫颈Bishop评分≤6的孕妇78例为研究对象,随机分为两组。研究组39例,阴道后穹窿放置欣普贝生;对照组39例,静脉输注催产素。比较两组宫颈Bishop评分、分娩结局、新生儿结局及不良反应。结果:研究组促宫颈成熟24 h有效率(92.31%)高于对照组(71.79%),差异有统计学意义(P<0.05);研究组临产时间、分娩时间均短于对照组,差异有统计学意义(P<0.05);研究组的阴道分娩率(76.92%)高于对照组(51.28%),差异有统计学意义(P<0.05);产后出血率、宫内感染率、胎儿窘迫率及新生儿窒息率差异均无统计学意义(P>0.05)。研究组的主要不良反应是宫缩过频及子宫过度刺激,取药后好转。结果:欣普贝生用于足月胎膜早破计划分娩是安全有效的。
Objective: To investigate the efficacy and safety of dinoprostone (Xin P bei sheng) for term preterm premature rupture of membranes. Methods: Select full-term premature rupture of membranes with planned indications for delivery. 78 pregnant women with cervical Bishop score ≤6 were randomly divided into two groups. The study group, 39 cases of vaginal posterior fornix Placenta; control group, 39 cases, intravenous infusion of oxytocin. The Bishop cervical score, delivery outcome, neonatal outcome and adverse reactions were compared between the two groups. Results: The effective rate of cervical ripening 24 h (92.31%) in the study group was significantly higher than that of the control group (71.79%), the difference was statistically significant (P <0.05). The labor hours and labor hours in the study group were shorter than those in the control group (P0.05) .The vaginal delivery rate (76.92%) in the study group was higher than that in the control group (51.28%), the difference was statistically significant (P0.05); the rate of postpartum hemorrhage, intrauterine infection rate, fetal distress Rate and neonatal asphyxia rate differences were not statistically significant (P> 0.05). The main adverse reactions in the study group were over-uterine contractions and over-stimulation of the uterus, which improved after taking medicine. Results: It is safe and effective to use Xinpeibesheng for full-term premature rupture of membranes.