论文部分内容阅读
目的对HIV/AIDS合并肺结核患者T-SPOT.TB结果进行分析,讨论HIV/AIDS合并肺结核患者CD4水平对T-SPOT.TB结果的影响。方法采用T-SPOT.TB对确诊且未进行抗结核治疗的51例HIV/AIDS合并肺结核患者和58例肺结核患者的外周血进行检测。结果 T-SPOT.TB在全部HIV/AIDS合并肺结核患者组、CD4>200/μl组、CD4≤200/μl组、肺结核患者组中的阳性检出率分别是74.5%(38/51)、83.3%(15/18)、69.7%(23/33)、91.4%(53/58)。各组之间阳性检出率比较,肺结核组高于HIV/AIDS合并肺结核组(P<0.05),肺结核组高于CD4≤200/μl组(P<0.05),肺结核组高于CD4>200/μl组(P>0.05),HIV/AIDS合并肺结核组低于CD4>200/μl组(P>0.05),HIV/AIDS合并肺结核组高于CD4≤200/μl组(P>0.05),CD4>200/μl组高于CD4≤200/μl组(P>0.05)。结论 HIV/AIDS合并肺结核患者CD4水平对T-SPOT.TB结果有一定的影响,当CD4≤200/μl时,T-SPOT.TB在HIV/AIDS合并肺结核中的阳性检出率明显降低,对结核感染的诊断存在一定困难,值得临床关注。
Objective To analyze the results of T-SPOT.TB in HIV / AIDS patients with pulmonary tuberculosis and to discuss the effect of CD4 level on the T-SPOT.TB in HIV / AIDS patients with pulmonary tuberculosis. Methods T-SPOT.TB was used to detect the peripheral blood of 51 cases of HIV / AIDS patients with tuberculosis and 58 cases of pulmonary tuberculosis who were diagnosed as non-TB patients. Results The positive rates of T-SPOT.TB were 74.5% (38/51) in all HIV / AIDS patients with pulmonary tuberculosis, CD4> 200 / μl, CD4≤200 / μl, and pulmonary tuberculosis % (15/18), 69.7% (23/33), 91.4% (53/58). The positive rate of tuberculosis was higher than that of HIV / AIDS complicated with tuberculosis (P <0.05), tuberculosis was higher than CD4≤200 / (P> 0.05), HIV / AIDS with pulmonary tuberculosis was lower than CD4> 200 / μl (P> 0.05), HIV / AIDS with pulmonary tuberculosis was higher than CD4≤200 / 200 / μl group than CD4≤200 / μl group (P> 0.05). Conclusion The CD4 level of HIV / AIDS patients with pulmonary tuberculosis has a certain effect on the T-SPOT.TB results. When CD4≤200 / μl, the positive rate of T-SPOT.TB in HIV / AIDS complicated pulmonary tuberculosis was significantly lower, There are some difficulties in the diagnosis of tuberculosis and it deserves clinical attention.